Table of Contents
ISRN Rheumatology
Volume 2012, Article ID 215692, 5 pages
Clinical Study

The Risk Factors for Nosocomial Infection in Chinese Patients with Active Rheumatoid Arthritis in Shanghai

1Department of Rheumatology and Immunology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
2Department of Rheumatology and Immunology, Shanghai Guanghua Hospital, Shanghai 200052, China
3Department of Rheumatology and Immunology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
4Department of Rheumatology and Immunology, Shanghai Longhua Hospital, Shanghai 200032, China
5Department of Rheumatology and Immunology, Yueyang Hospital of Integrated Traditional and Western Medicine, Shanghai 200473, China
6Department of Rheumatology and Immunology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai 200071, China
7Department of Rheumatology and Immunology, Shanghai First People’s Hospital, Shanghai 201620, China
8Department of Rheumatology and Immunology, Shidong Hospital, Shanghai 200438, China
9Department of Rheumatology and Immunology, No.3 People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201900, China
10Department of Rheumatology and Immunology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
11Department of Rheumatology and Immunology, Huashan Hospital, Shanghai 200040, China
12Department of Rheumatology and Immunology, Renji Hospital, Shanghai 200003, China
13Department of Immunology and Rheumatology, Huadong Hospital, Fudan University, Yananxi Road, Shanghai 200040, China

Received 7 December 2011; Accepted 15 January 2012

Academic Editors: A. Adebajo, A. H. Gerards, and A. Kessel

Copyright © 2012 Wei-Lin Xie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To analyse the potential risk factors of nosocomial infections in patients with active rheumatoid arthritis (RA). Methods. A total of 2452 active RA patients at Hospitals in Shanghai between January 2009 and February 2011 were analyzed. Their demographic and clinical characteristics were compared with those without infection, and the potential risk factors were determined by logistic regression analysis. Results. Multivariate analysis indicated the gender ( O R = 0 . 7 0 , 95% CI 0.53–0.92), duration in hospital ( O R = 1 . 0 3 , 95%CI 1.01–1.05), number of organs involved ( O R = 0 . 8 2 , 95%CI 0.72–0.92), number of disease-modifying antirheumatic drugs ((DMARDs) ( O R = 1 . 2 2 , 95%CI 1.061–1.40)), corticosteroid therapy ( O R = 1 . 0 2 , 95%CI 1.01–1.03), peripheral white blood cell counts ((WBC) ( O R = 1 . 0 4 , 95%CI 1.00–1.08)), levels of serum albumin ( O R = 0 . 9 8 , 95%CI 0.97–0.99), and C-reactive protein ((CRP) ( O R = 1 . 0 3 , 95%CI 1.01–1.04)) that were significantly associated with the risk of infections. Conclusion. The female patients, longer hospital stay, more organs involved, more DMARDs, corticosteroid usage, high counts of WBC, lower serum albumin, and higher serum CRP were independent risk factors of infections in active RA patients.