Review Article
Insulin Therapy and Cancer in Type 2 Diabetes
Table 1
Epidemiological studies on the association of insulin treatment with cancer incidence or cancer-related mortality in type 2 diabetes.
| |
Study [Ref.] |
Outcome |
Main result* | | | | Confounders | | | | |
Adiposity |
Duration DM |
Glucose control |
Comorbidities |
Medications |
Ethnicity |
Socioeconomic |
Education |
Smoking |
Alcohol |
Dietary factors |
Physical activity |
| | Studies included in the meta-analysis of Janghorbani et al. [44] | | Yang et al., 2004 [31] | Colorectal cancer | 2.10 [1.20–3.40] | + | + | − | − | + | − | − | − | + | − | − | − | | Bowker et al., 2006 [32] | Cancer mortality | 1.90 [1.50–2.40] | − | − | − | + | − | − | − | − | − | − | − | − | | Monami et al., 2008 [33] | Cancer mortality | 2.11 [1.01–4.50] | + | + | + | + | + | − | − | − | + | + | − | − | | Colhoun, 2009 [40] | All cancers | 1.73 [0.98–3.05] | + | − | + | − | + | − | + | − | + | − | − | − | | Currie et al., 2009 [34] | All cancers | 1.42 [1.27–1.60] | + | − | + | + | + | − | − | − | + | − | − | − | | Hemkens et al., 2009 [35] | All cancers | 1.19 [1.09–1.29] | − | − | − | − | + | − | − | − | − | − | − | − | | Jonasson et al., 2009 [45] | All cancers | 1.06 [0.90–1.25] | + | + | − | + | − | − | − | + | + | − | − | − | | Li et al., 2009 [36] | Pancreatic cancer | 4.99 [2.59–9.61] | + | − | − | − | − | + | − | − | + | + | − | − | | Monami et al., 2009 [46] | All cancers | 1.01 [0.64–1.59] | + | + | + | + | + | − | − | − | + | + | − | − | | Vinikoor et al., 2009 [42] | Colorectal cancer | 1.74 [0.92–3.31] | + | − | − | − | + | + | + | + | + | − | + | + | | Campbell et al., 2010 [47] | Colorectal cancer | 1.02 [0.79–1.30] | + | − | − | − | + | + | + | + | + | + | + | + | | Donadon et al., 2010 [48] | Hepatocellular carcinoma | 1.24 [0.45–3.36] | + | + | + | − | + | − | − | − | − | + | − | − | | Hassan et al., 2010 [41] | Hepatocellular carcinoma | 1.90 [0.80–4.60] | − | − | − | − | − | − | − | + | + | + | − | − | | Yang et al., 2010 [2] | All cancers | 0.17 [0.09–0.32] | − | + | − | + | + | − | − | − | − | + | − | − | | Baur et al., 2011 [37] | All cancers | 3.87 [1.53–9.81] | + | − | + | − | − | − | − | − | + | − | − | − |
| | Other studies | | Tseng, 2011 [43] | Bladder cancer | 1.43 [0.90–2.26] | − | − | − | + | + | − | + | − | − | − | − | − | | Bodmer et al., 2012 [38] | Pancreatic cancer | 2.29 [1.34–3.92] | + | + | − | − | − | − | − | − | + | + | − | − | | Van Staa et al., 2012 [39] | All cancers | 1.79 [1.53-2.10] | + | − | − | + | + | − | − | − | + | + | − | − |
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