Table of Contents
ISRN Dermatology
Volume 2012, Article ID 257059, 4 pages
Research Article

Expression of Nuclear Factor Kappa B and Survivin in Psoriasis

1Department of Dermatology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey
2Department of Pathology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey

Received 1 October 2012; Accepted 3 November 2012

Academic Editors: C. Ferrándiz and S. Inui

Copyright © 2012 Kamer Gunduz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background and Objective. Suppression of apoptosis has been proposed as a mechanism responsible for epidermal thickness in psoriasis. Survivin is a member of the inhibitor of apoptosis family. Nuclear factor kappa B (NF-κB) is one of the transcriptional factors that regulate many genes affecting apoptosis. The aim of this study was to determine survivin and NF-κB expressions in psoriasis in comparison with normal epidermis. Patients and Methods. Immunohistochemical expressions of survivin and NF-κB were investigated in 41 psoriatic and 21 normal skin samples. Results. Diffuse nuclear survivin expression in all epidermal layers was seen in all of the psoriatic samples. NF-κB expression in different epidermal locations was seen in all of the psoriatic samples. Nuclear staining was positive in 40 psoriasis samples. Similar survivin and NF-κB expressions were observed in normal skin samples. Conclusion. Since similar expressions are seen in both normal and psoriatic epidermis, no important roles for survivin and NF-κB can be attributed in epidermal proliferation and thickness seen in psoriasis.