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| Study | Type of study | Efficacy measure | Results |
|
| Doft and Blankenship [16] | Prospective study. 54 eyes included, with a six-month
followup | Proportion of eyes that showed reduced levels of severity and had 3 or more risk factors | 72% of these eyes remained stable three weeks after PRP
72% of these eyes remained stable at a six-month visit |
| Vander et al. [17] | Retrospective study. 59 eyes included, with a twelve-month followup | NVD moderate-severe: reduction of NVD in 1/3 of DA
Mild NVD: complete regression of NVD
| Regression was observed in 62% of these eyes six months after PRP |
| Reddy et al. [18] | Retrospective study. 294 eyes included, with a twelve-month followup | 4 high-risk characteristics: reduction to 2 or less
2 high-risk characteristics: reduction to 1 | Regression was observed in 77% of these eyes one year after PRP |
Bandello et al. [9]
| Prospective, comparative and randomised study. 9 eyes included per group, with a twelve-month followup | Reduction of the leakage area of the new vessels based on FA
| Observations at three, six, and nine months revealed that 19%, 22%, and 33% reductions of the leakage area, respectively, occurred in the eyes that were treated with laser therapy
Observations at one, six, and nine months revealed that 74%, 84%, and 86% reductions of the leakage area, respectively, occurred in the eyes that were treated with laser therapy and IVT |
| Zein et al. [10] | Prospective study. 35 eyes included with a nine-month followup, and data were compared retrospectively with medical records | Stabilisation: regression or no progression of the new vessels | 100% of the eyes in the laser group at a nine-month visit
100% of eyes treated with the combination of laser and IVT |
| IBehi study [14] | Prospective, comparative and randomised study. 15 eyes included per group, with a six-month followup | Reduction of the leakage area of the new vessel based on FA
| 3.78%, 6.8%, and 11.2% in eyes treated with laser therapy (four, nine, and sixteen weeks, resp.)
94.5%, 93.99%, and 60% in eyes treated with laser therapy and IVB (four, nine, and sixteen weeks, resp.) |
| Cho et al. [19] | Prospective, comparative and randomised study. 19 eyes included per group, with a three-month followup | Worsening severity of the retinopathy | 20% of eyes treated with laser therapy after three months
0% of eyes treated with laser and IVB after three months |
|
Lopez-Lopez et al. | Prospective, comparative study. The first 40 eyes were randomised (1 : 1) to a PRP group or to an IVT group. The IVB group included 20 consecutive eyes that met the inclusion criteria. Six-month followup | Complete absence of leakage based on FA after treatment was applied | 33% and 27.5% in eyes treated with laser therapy (two and six months, resp.)
71.2% and 74.4% in eyes treated with laser therapy and IVT (two and six months, resp.)
98.9% and 76.8% in eyes treated with laser therapy and IVB (two and six months, resp.)
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