International Scholarly Research Notices / 2012 / Article / Fig 3

Research Article

Neural Circuit in the Dorsal Raphe Nucleus Responsible for Cannabinoid-Mediated Increases in 5-HT Efflux in the Nucleus Accumbens of the Rat Brain

Figure 3

Effect of reverse dialysis infusion of WIN 55,212-2 on 5-HT efflux in the DRN (a) or NAcc (b). Data are expressed as percent of average baseline values (% mean ± s.e.m.). Note that 1 μM citalopram was included in the infusion medium. Mean baseline level of extracellular 5-HT was 3 . 3 5 ± 0 . 0 6  pg/sample in the DRN ( 𝑛 = 2 3 ) and 4 . 1 5 ± 0 . 7 9  pg/sample in the NAcc ( 𝑛 = 2 4 ). The open horizontal bars indicate the 30-min period of drug infusion. (a) WIN 55,212-2 (100, 300 and 1000 μM) produced a concentration-dependent increase in 5-HT efflux in the DRN. (b) WIN 55,212-2 (100, 300, and 1000 μM) produced a concentration-dependent decrease in 5-HT efflux in the NAcc. * 𝑃 < 0 . 0 5 , ** 𝑃 < 0 . 0 1 and *** 𝑃 < 0 . 0 0 1 versus vehicle examined by the repeated measures ANOVA followed by post hoc Scheffe test.
276902.fig.003a
(a)
276902.fig.003b
(b)

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