Research Article
N-Aryl Lactams by Regioselective Ozonation of N-Aryl Cyclic Amines
Table 1
Conversion and isolated yields in 4-(4-nitrophenyl)-morpholin-3-one (4) after ozonation of 4-(4-nitrophenyl)-morpholine (3) at different experimental conditions (DCM: dichloromethane, CAN: acetonitrile, EA: ethyl acetate).
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a100 mg of 4-(4-nitrophenyl)-morpholine (3) were dissolved in 50 mL of solvent and ozonized at the selected temperature for the selected time. When the reactions were carried out with a limited amount of ozone, 30 mg 4-(4-nitrophenyl)morpholine (3) were dissolved in the required amount of solvent. Ozone concentrations were estimated on the basis of the iodometric method [25]. bConversions are calculated on the recovered 4-(4-nitrophenyl)morpholine. cGC-MS yield. dFor the conditions see the experimental section. |