Anticonvulsant Drugs, Brain Glutamate Dehydrogenase Activity and Oxygen Consumption
Effect in vitro of some anticonvulsant drugs on glutamate oxidative deamination catalized by mouse brain glutamate dehydrogenase. Glutamate dehydrogenase activity (GDH) was determined in mouse brain homogenates (1 : 5 w : v on phosphates 0.05 M pH = 7.6 buffer) with different concentrations of pyridoxal phosphate (PPAL), hydroxylamine (OHAMINE) and aminooxyacetic acid (AAOA) with glutamic acid as substrate, using a spectrophotometric method (see Section 2). Results are means ± SEM (). ANOVA test was applied and different characters were used to indicate statistically different groups as compared with the control (, Tuckey’s test).
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