Anticonvulsant Drugs, Brain Glutamate Dehydrogenase Activity and Oxygen Consumption
Effect in vitro of aminooxiacetic and hydroxylamine on glutamate dehydrogenase activity of different sources. Effect of different concentrations of aminooxyacetic acid (AAOA), and hydroxylamine (OHAMINE) on reductive amination of α-ketoglutarate and oxidative deamination of glutamate respectively, catalyzed by glutamate dehydrogenase commercially available (from bovine liver), mouse brain, and liver homogenates (1 : 5 w : v on phosphates 0.05 M pH = 7.6 buffer), using a spectrophotometric method (see Section 2). Results are means ± SEM (). ANOVA test was applied, and different characters were used to indicate statistically different groups as compared with the control (, Tuckey’s test).
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