International Scholarly Research Notices / 2012 / Article / Fig 6

Research Article

Anticonvulsant Drugs, Brain Glutamate Dehydrogenase Activity and Oxygen Consumption

Figure 6

Effect in vitro of some anticonvuulsant drugs on oxygen consumption. Different concentrations of pyridoxal phosphate (PPAL), hydroxylamine (OHAMINE), and aminooxyacetic acid (AAOA) were added and oxygen consumption was determined in mouse brain homogenates (25% wt/vol in sucrose 0.25 M) by a polarographic method using glutamate (a) and α-ketoglutarate (b) as substrates (see Section 2). Results are means ± SEM ( 𝑛 > 4 ). ANOVA test was applied and different characters were used to indicate statistically different groups as compared with the control ( 𝑃 > 0 . 0 1 , Tuckey’s test).
(a) Glutamate
(b) α-ketoglutarate

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