Anticonvulsant Drugs, Brain Glutamate Dehydrogenase Activity and Oxygen Consumption
Effect in vivo of some anticonvulsant drugs on oxygen consumption. Animals received pyridoxal phosphate (PPAL, 50 mg/Kg), hydroxylamine (OHAMINE, 40 mg/kg), and aminooxyacetic acid (AAOA, 40 mg/Kg). After the treatment, oxygen consumption was determined in brain homogenates (25% wt/vol in sucrose 0.25 M), by a polarographic method using glutamate (a) and α-ketoglutarate (b) as substrates (see Section 2). Results are means ± SEM (). *Statistically significant differences as compared with the control (, Student’s test).
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