Table of Contents
ISRN Pharmacology
Volume 2012 (2012), Article ID 307102, 10 pages
http://dx.doi.org/10.5402/2012/307102
Research Article

Menadione : Sodium Orthovanadate Combination Eliminates and Inhibits Migration of Detached Cancer Cells

1Department of Clinical Neuroscience, Karolinska Institute, Karolinska University Hospital, 141 86 Stockholm, Sweden
2Brain Research Centre, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
3Department of Neurology, Karolinska University Hospital, 141 86 Stockholm, Sweden

Received 25 April 2012; Accepted 5 July 2012

Academic Editors: J. C. Clapham, G. Edwards, R. Fantozzi, and S. Kitayama

Copyright © 2012 Zahid M. Delwar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. M. Nelson and J. Tien, “Microstructured extracellular matrices in tissue engineering and development,” Current Opinion in Biotechnology, vol. 17, no. 5, pp. 518–523, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. S. H. Kim, J. Turnbull, and S. Guimond, “Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor,” Journal of Endocrinology, vol. 209, no. 2, pp. 139–151, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. J. L. Au, R. R. Kumar, D. Li, and M. G. Wientjes, “Kinetics of hallmark biochemical changes in paclitaxel-induced apoptosis,” The AAPS Journal, vol. 1, no. 3, article 8, pp. 7–14, 1999. View at Publisher · View at Google Scholar · View at Scopus
  4. S. M. Frisch and H. Francis, “Disruption of epithelial cell-matrix interactions induces apoptosis,” Journal of Cell Biology, vol. 124, no. 4, pp. 619–626, 1994. View at Google Scholar · View at Scopus
  5. C. Horbinski, C. Mojesky, and N. Kyprianou, “Live free or die: tales of homeless (cells) in cancer,” American Journal of Pathology, vol. 177, no. 3, pp. 1044–1052, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Sakamoto and N. Kyprianou, “Targeting anoikis resistance in prostate cancer metastasis,” Molecular Aspects of Medicine, vol. 31, no. 2, pp. 205–214, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Douma, T. Van Laar, J. Zevenhoven, R. Meuwissen, E. Van Garderen, and D. S. Peeper, “Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB,” Nature, vol. 430, no. 7003, pp. 1034–1039, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. X. C. Wang, Y. P. Wu, B. Ye et al., “Suppression of anoikis by SKP2 amplification and overexpression promotes metastasis of esophageal squamous cell carcinoma,” Molecular Cancer Research, vol. 7, no. 1, pp. 12–22, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. R. R. Langley and I. J. Fidler, “The seed and soil hypothesis revisited—the role of tumor-stroma interactions in metastasis to different organs,” International Journal of Cancer, vol. 128, no. 11, pp. 2527–2535, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. A. I. Marcus and W. Zhou, “LKB1 regulated pathways in lung cancer invasion and metastasis,” Journal of Thoracic Oncology, vol. 5, no. 12, pp. 1883–1886, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Keledjian and N. Kyprianou, “Anoikis induction by quinazoline based α1-adrenoceptor antagonists in prostate cancer cells: antagonistic effect of bcl-2,” The Journal of Urology, vol. 169, no. 3, pp. 1150–1156, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. M. L. Wahl, C. S. Owen, and D. S. Grant, “Angiostatin induces intracellular acidosis and anoikis in endothelial cells at a tumor-like low pH,” Endothelium, vol. 9, no. 3, pp. 205–216, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. L. Kočí, M. Hýžd'alová, A. Vaculová, J. Hofmanová, and A. Kozubík, “Detachment-mediated resistance to TRAIL-induced apoptosis is associated with stimulation of the PI3K/Akt pathway in fetal and adenocarcinoma epithelial colon cells,” Cytokine, vol. 55, no. 1, pp. 34–39, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. T. Zeeli, M. Langberg, C. Rotem, M. David, R. Koren, and A. Ravid, “Vitamin D inhibits captopril-induced cell detachment and apoptosis in keratinocytes,” British Journal of Dermatology, vol. 164, no. 1, pp. 62–67, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. C. M. Díaz-Montero and B. W. McIntyre, “Acquisition of anoikis resistance in human osteosarcoma cells does not alter sensitivity to chemotherapeutic agents,” BMC Cancer, vol. 5, article 39, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Blanchard and C. Le Péchoux, “Prophylactic cranial irradiation in lung cancer,” Current Opinion in Oncology, vol. 22, no. 2, pp. 94–101, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. W. Schuette, “Treatment of brain metastases from lung cancer: chemotherapy,” Lung Cancer, vol. 45, supplement 2, pp. S253–S257, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Yamanaka, “Medical management of brain metastases from lung cancer (review),” Oncology Reports, vol. 22, no. 6, pp. 1269–1276, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. D. R. Laks, K. Visnyei, and H. I. Kornblum, “Brain tumor stem cells as therapeutic targets in models of glioma,” Yonsei Medical Journal, vol. 51, no. 5, pp. 633–640, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Cruz, Å. Siden, D. R. Tasat, and J. S. Yakisich, “Are all glioma cells cancer stem cells?” Journal of Cancer Science and Therapy, vol. 2, no. 4, pp. 100–106, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. M. A. Hatiboglu, J. Wei, A. S. G. Wu, and A. B. Heimberger, “Immune therapeutic targeting of glioma cancer stem cells,” Targeted Oncology, vol. 5, no. 3, pp. 217–227, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. Z. M. Delwar, D. Avramidis, E. Follin et al., “Cytotoxic effect of menadione and sodium orthovanadate in combination on human glioma cells,” Investigational New Drugs, vol. 30, no. 4, pp. 1302–1310, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. M. F. Vita, N. Nagachar, D. Avramidis et al., “Pankiller effect of prolonged exposure to menadione on glioma cells: potentiation by vitamin C,” Investigational New Drugs, vol. 29, no. 6, pp. 1314–1320, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. D. Avramidis, M. Cruz, Å. Sidén, D. R. Tasat, and J. S. Yakisich, “Regrowth concentration zero (RC0) as complementary endpoint parameter to evaluate compound candidates during preclinical drug development for cancer treatment,” Journal of Cancer Science & Therapy, vol. 1, pp. 19–24, 2009. View at Publisher · View at Google Scholar
  25. J. Carmichael, J. B. Mitchell, W. G. DeGraff et al., “Chemosensitivity testing of human lung cancer cell lines using the MTT assay,” British Journal of Cancer, vol. 57, no. 6, pp. 540–547, 1988. View at Google Scholar · View at Scopus
  26. T. Mosmann, “Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays,” Journal of Immunological Methods, vol. 65, no. 1-2, pp. 55–63, 1983. View at Google Scholar · View at Scopus
  27. T. Miyamoto, W. Min, and H. S. Lillehoj, “Lymphocyte proliferation response during Eimeria tenella infection assessed by a new, reliable, nonradioactive colorimetric assay,” Avian Diseases, vol. 46, no. 1, pp. 10–16, 2002. View at Google Scholar · View at Scopus
  28. T. Akiyoshi, S. Matzno, M. Sakai, N. Okamura, and K. Matsuyama, “The potential of vitamin K3 as an anticancer agent against breast cancer that acts via the mitochondria-related apoptotic pathway,” Cancer Chemotherapy and Pharmacology, vol. 65, no. 1, pp. 143–150, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. J. M. Jamison, J. Gilloteaux, M. Venugopal et al., “Flow cytometric and ultrastructural aspects of the synergistic antitumor activity of vitamin C-vitamin K3 combinations against human prostatic carcinoma cells,” Tissue and Cell, vol. 28, no. 6, pp. 687–701, 1996. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Venugopal, J. M. Jamison, J. Gilloteaux et al., “Synergistic antitumor activity of vitamins C and K3 on human urologic tumor cell lines,” Life Sciences, vol. 59, no. 17, pp. 1389–1400, 1996. View at Publisher · View at Google Scholar · View at Scopus
  31. J. A. Gordon, “Use of vanadate as protein-phosphotyrosine phosphatase inhibitor,” Methods in Enzymology, vol. 201, pp. 477–482, 1991. View at Google Scholar · View at Scopus
  32. M. A. M. Capella, L. S. Capella, R. C. Valente, M. Gefé, and A. G. Lopes, “Vanadate-induced cell death is dissociated from H2O2 generation,” Cell Biology and Toxicology, vol. 23, no. 6, pp. 413–420, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. P. Bonomi, “Matrix metalloproteinases and matrix metalloproteinase inhibitors in lung cancer,” Seminars in Oncology, vol. 29, no. 1, supplement 4, pp. 78–86, 2002. View at Google Scholar · View at Scopus
  34. S. Charvat, C. Le Griel, M. C. Chignol, D. Schmitt, and M. Serres, “Ras-transfection up-regulated HaCaT cell migration: inhibition by Marimastat,” Clinical and Experimental Metastasis, vol. 17, no. 8, pp. 677–685, 1999. View at Publisher · View at Google Scholar · View at Scopus
  35. J. C. Tonn, S. Kerkau, A. Hanke et al., “Effect of synthetic matrix-metalloproteinase inhibitors on invasive capacity and proliferation of human malignant gliomas in vitro,” International Journal of Cancer, vol. 80, no. 5, pp. 764–772, 1999. View at Google Scholar
  36. L. Bonmassar, E. Fossile, A. Scoppola et al., “Detection of circulating tumor cells is improved by drug-induced antigen up-regulation: preclinical and clinical studies,” Anticancer Research, vol. 30, no. 11, pp. 4721–4730, 2010. View at Google Scholar · View at Scopus
  37. T. Koga, E. Tokunaga, Y. Sumiyoshi et al., “Detection of circulating gastric cancer cells in peripheral blood using real time quantitative RT-PCR,” Hepato-Gastroenterology, vol. 55, no. 84, pp. 1131–1135, 2008. View at Google Scholar · View at Scopus
  38. J. Y. Wang, C. H. Wu, C. Y. Lu et al., “Molecular detection of circulating tumor cells in the peripheral blood of patients with colorectal cancer using RT-PCR: significance of the prediction of postoperative metastasis,” World Journal of Surgery, vol. 30, no. 6, pp. 1007–1013, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. E. W. Howard, S. C. L. Leung, H. F. Yuen et al., “Decreased adhesiveness, resistance to anoikis and suppression of GRP94 are integral to the survival of circulating tumor cells in prostate cancer,” Clinical and Experimental Metastasis, vol. 25, no. 5, pp. 497–508, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. I. J. Fidler, S. Yano, R. D. Zhang, T. Fujimaki, and C. D. Bucana, “The seed and soil hypothesis: vascularisation and brain metastases,” The Lancet Oncology, vol. 3, no. 1, pp. 53–57, 2002. View at Publisher · View at Google Scholar · View at Scopus
  41. M. Kimata, Y. Otani, T. Kubota et al., “Matrix metalloproteinase inhibitor, marimastat, decreases peritoneal spread of gastric carcinoma in nude mice,” Japanese Journal of Cancer Research, vol. 93, no. 7, pp. 834–841, 2002. View at Google Scholar · View at Scopus
  42. K. I. Maekawa, H. Sato, M. Furukawa, and T. Yoshizaki, “Inhibition of cervical lymph node metastasis by marimastat (BB-2516) in an orthotopic oral squamous cell carcinoma implantation model,” Clinical and Experimental Metastasis, vol. 19, no. 6, pp. 513–518, 2002. View at Publisher · View at Google Scholar · View at Scopus
  43. V. Kumar Khanna, “Targeted delivery of nanomedicines,” ISRN Pharmacology, vol. 2012, Article ID 571394, 9 pages, 2012. View at Google Scholar
  44. M. Rahman, M. Z. Ahmad, I. Kazmi et al., “Emergence of Nanomedicine as cancer targeted magic bullets: recent development and need to address the toxicity apprehension,” Current Drug Discovery Technologies. In press.
  45. F. I. Staquicini, M. G. Ozawa, C. A. Moya et al., “Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma,” The Journal of Clinical Investigation, vol. 121, no. 1, pp. 161–173, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. T. Noda, S. Iwai, M. Hamada, Y. Fujita, and Y. Yura, “Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol. Possible role of Bim, focal adhesion kinase and endonuclease G,” Apoptosis, vol. 14, no. 3, pp. 287–297, 2009. View at Publisher · View at Google Scholar · View at Scopus