Table of Contents
ISRN Pharmacology
Volume 2012, Article ID 309084, 6 pages
http://dx.doi.org/10.5402/2012/309084
Research Article

Examination of Haematotoxicity of Fixed-Dose Highly Active Antiretroviral Drug in Albino Wistar Rats

1Department of Medical Laboratory Sciences, Faculty of Health Sciences and Technology, College of Medicine, University of Nigeria, Enugu Campus, Enugu State, Enugu 400001, Nigeria
2Department of Pharmacology and Therapeutics, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Enugu Campus, PMB 01129, Enugu State, Enugu 400001, Nigeria
3Department of Haematology, University of Nigeria Teaching Hospital (UNTH), Ituku-Ozalla, PMB 01129, Enugu State, Enugu 400001, Nigeria

Received 16 September 2012; Accepted 18 October 2012

Academic Editors: G. Biala and R. Fantozzi

Copyright © 2012 Thomas Nubila et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Highly active antiretroviral therapy (HAART) is considered toxic and has other life-threatening side effects. Our aim was to evaluate the haematotoxic effects of lamivudine, zidovudine, and nevirapine fixed-dose combinations in Albino Wistar rats. Fifty (50) three (3) months old male Albino Wistar rats weighing between 200 and 250 g were randomly assigned to five (5) groups (A, B, C, D, and E). Group A served as control. Two (2 mLs) of venous blood was aseptically collected on Days 5, 10, 15, 20, and 25 of treatment. Red blood cell (RBC) mean value recorded statistically significant increase ( ) in groups B and C when compared with the control group on Day 5. However, there was a statistically significant decrease ( ) in RBC, haemoglobin concentration (Hb), packed cell volume (PCV), and some red cell indices on Day 10. In addition there was no statistically significant difference ( ) in all the parameters evaluated when the test group was compared with the control on Day 25. Furthermore, there was a time-related statistically significant increase ( ) in the two major blood cells—RBC and platelet counts. From the result of this present study, it can be concluded that HAART when administered in fixed-dose combinations have no subacute haematotoxic effects.