Table of Contents
ISRN Pediatrics
Volume 2012, Article ID 317280, 4 pages
Clinical Study

Urinary Tract Infection Prophylaxis in Children with Neurogenic Bladder with Cranberry Capsules: Randomized Controlled Trial

1Yuksekova Government Hospital, Hakkari, Turkey
2Department of Pediatric Nephrology, Kocaeli University Hospital, Umuttepe, 41380 Kocaeli, Turkey

Received 5 March 2012; Accepted 10 May 2012

Academic Editors: T. Hegyi, S. K. Patole, and K. Tokiwa

Copyright © 2012 Hatice Mutlu and Zelal Ekinci. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. The aim of this randomized controlled prospective study is to evaluate the efficacy of cranberry capsules for prevention of UTI in children with neurogenic bladder caused by myelomeningocele. Patients and Methods. To be eligible for this study, patients had to be diagnosed as neurogenic bladder caused by myelomeningocele, evaluated urodynamically, followed up with clean intermittent catheterization and anticholinergic drugs. Intervention. Six months of treatment with placebo; after a week of wash-out period treatment of cranberry extract tablets (1 capsule/day) for an additional 6 months. Randomization was performed sequentially. Patients and care givers were blinded to drug assignment. Main outcome measure was infection rate. Group comparisons were performed with Wilcoxon test. Results. The study population included 20 (F/M: 13/7) patients with neurogenic bladder with the mean age of 7 . 2 5 Β± 3 . 4 9 (4, 18) years. The median UTI rate was 0.5/year during placebo usage whereas 0/year during cranberry capsule usage. Decrease in infection rate was significant with cranberry capsule usage ( 𝑃 = 0 . 0 1 2 ). Decrease in the percentage of the pyuria was also recorded as significant ( 𝑃 = 0 . 0 0 0 ). Any adverse events or side effects were not recorded. Conclusion. We concluded that cranberry capsules could be an encouraging option for the prevention of recurrent UTI in children with neurogenic bladder caused by myelomeningocele.