Table of Contents
ISRN Endocrinology
Volume 2012, Article ID 318194, 14 pages
Review Article

Organ-Based Response to Exercise in Type 1 Diabetes

Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, KS 66160, USA

Received 23 October 2012; Accepted 14 November 2012

Academic Editors: J.-M. Ricort, N. Tentolouris, K. Yamagami, and K. Zajickova

Copyright © 2012 Lisa Stehno-Bittel. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


While significant research has clearly identified sedentary behavior as a risk factor for type 2 diabetes and its subsequent complications, the concept that inactivity could be linked to the complications associated with type 1 diabetes (T1D) remains underappreciated. This paper summarizes the known effects of exercise on T1D at the tissue level and focuses on the pancreas, bone, the cardiovascular system, the kidneys, skeletal muscle, and nerves. When possible, the molecular mechanisms underlying the benefits of exercise for T1D are elucidated. The general benefits of increased activity on health and the barriers to increased exercise specific to people with T1D are discussed.