Table of Contents
ISRN Neurology
Volume 2012 (2012), Article ID 320607, 7 pages
Clinical Study

The Effect of Pramipexole Therapy on Balance Disorder and Fall Risk in Parkinson’s Disease at Early Stage: Clinical and Posturographic Assessment

1Department of Neurology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey
2Department of Neurology, Faculty of Medicine, Pamukkale University, 20070 Denizli, Turkey
3Department of Biostatistics, Faculty of Medicine, Pamukkale University, 20070 Denizli, Turkey
4Department of Physical Treatment and Rehabilitation, Faculty of Medicine, Pamukkale University, 20070 Denizli, Turkey

Received 3 April 2012; Accepted 5 June 2012

Academic Editors: D. Dewar and B. Drukarch

Copyright © 2012 Sibel Güler et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study was to determine balance problems and severity and ratio of postural instability of newly diagnosed, early stage Parkinson’s patients who did not receive any antiparkinson treatment before, to evaluate fall risk clinically and posturographically and to examine the effects of pramipexole on these signs and symptoms. Detailed posturographic assessments which involved central vestibular, visual, peripheric vestibular somatosensory field tests were applied to both patient and control subjects and fall risk was determined. There was not statistically significant difference between patients and control subjects before and after drug therapy in the assesment of fall risk in posturography and there was not any improvement with drug usage in the patient group. However, in the analysis of subsystems separately, only the involvement in central vestibular field was more severe and could appear at all positions in Parkinson’s patients comparing with the control group, and pramipexole was partially effective in improving this disorder. Central vestibular field is the subsystem that should be examined with first priority. Posturography is relatively reliable in defining fall risk and postural instability ratio in Parkinson’s disease. But it should be considered that clinical assessment tools can be more sensitive in the evaluation of balance and postural disorders and in the follow-up of the response to drug therapy.