The Florida Melanoma Trial I: A Prospective Multicenter Phase I/II Trial of Postoperative Hypofractionated Adjuvant Radiotherapy with Concurrent Interferon-Alfa-2b in the Treatment of Advanced Stage III Melanoma with Long-Term Toxicity Follow-Up
Table 9
Review of retrospective literature on combination of RT and IFN α-2b for melanoma.
5/10 severe subacute/late complications including two patients with peripheral neuropathy, one patient with radiation necrosis in the brain, and two patients with radiation necrosis in the subcutaneous tissue.
FFS at 3 years was 88%. All the patients experienced grade I acute skin reactions. Late toxicity was seen in one patient with grade III (RTOG) skin reaction and two with grade IV (RTOG) radiation-induced myelitis.
7/18 grade 3 skin reactions. Severe radiation-induced toxicity was seen in three patients, one who developed radiation pneumonitis, one who developed severe oral mucositis, and one who developed wound dehiscence.