Table 9: Review of retrospective literature on combination of RT and IFN α-2b for melanoma.


Hazard et al. [22]melanoma 𝑛 = 1 0 concurrent or within 1 month45–50 Gy5/10 severe subacute/late complications including two patients with peripheral neuropathy, one patient with radiation necrosis in the brain, and two patients with radiation necrosis in the subcutaneous tissue.

Conill et al. [23]melanoma 𝑛 = 1 8 concurrent or within 1 month30 Gy/5 fractions ( 𝑛 = 8 ), 36 Gy/6 fractions ( 𝑛 = 8 ) 50 Gy/25 fractions ( 𝑛 = 2 ).FFS at 3 years was 88%. All the patients experienced grade I acute skin reactions. Late toxicity was seen in one patient with grade III (RTOG) skin reaction and two with grade IV (RTOG) radiation-induced myelitis.

Gyorki et al. [24]melanoma 𝑛 = 1 8 concurrent40–50 Gy in 15–25 fractions7/18 grade 3 skin reactions. Severe radiation-induced toxicity was seen in three patients, one who developed radiation pneumonitis, one who developed severe oral mucositis, and one who developed wound dehiscence.

Nguyen et al. [25]melanoma 𝑛 = 3 concurrent41.4–66 GyAll three patients achieved local control at 24, 18 and 19 months followup; one patient developed widespread distant metastases.