Evaluation of Cytokines in Endocervical Secretion and Vaginal pH
from Women with Bacterial Vaginosis or Human Papillomavirus
Table 2
Concentration of IL-2, IL-12, TNF-α, IFN-γ, IL-6, and IL-10 (median, 25–75 percentil in pg/mL), in women with bacterial vaginosis (BV), HPV, HR HPV, and LR HPV.
Cytokines
IL-2
IL-12
TNF-α
IFN-γ
IL-6
IL-10
Groups (n)
HPV (47)
40.1 (24.3–77.8)1
92.3 (48.1–146.3)6, 19
40818 (20280–66630)
384.5 (269.3–644.4)19
979056 (384200–1191000)
142421 (79730–257000)16
HR HPV (31)
39.3 (23.6–85.7)2
92.3 (38.9–143.0)19
36090 (19520–62320)
375.0 (130.4–641.7)11, 19
892700 (139400–1170000)
149976 (85890–323300)17
LR HPV (22)
40.1 (24.0–91.7)
112.7 (53.9–177.9)7, 19
48170 (27120–76710)
407.0 (133.7–616.6)19
1038345 (573400–1223000)
131007 (68310–281100)
Only HPV (36)
36.3 (24.0–69.8)3, 19
90.5 (47.4–127.6)19
41680 (23080–66270)
4.6 (0.5–60.7)12
936400 (144600–1200000)
146100 (76670–276500)
Only HR HPV (19)
35.1 (24.1–58.1)19
91.9 (36.1–139.1)19
37030 (20280–66630)
2.8 (0.5–33.0)12, 20
621600 (57060–1079000)22
176500 (79730–323300)
Only LR HPV (12)
50.5 (24.0–69.8)19
82.8 (47.8–190.0)19
41680 (27410–66790)
50.8 (0.5–157.5)13
1038000 (567000–1200000)
131000 (68310–149800)
BV (47)
47.8 (21.9–90.6)4
104.1 (47.1–255.6)8
40996 (19520–71550)
421.6 (133.7–652.7)
976056 (403600–1316000)14
100763 (57490–224000)
Only BV (36)
47.8 (21.9–102.8)5
74.7 (44.4–261.8)9
41230 (17070–67460)
30.5 (6.2–70.4)
1099000 (346800–1413000)15
126400 (55910–235400)
BV and HPV (11)
55.4 (24.2–88.2)19
143.0 (53.7–272.3)10, 19
21820 (19520–75640)
30.4 (11.8.7–79.5)18
974300 (624100–1154000)
101700 (85890–257000)
BV and HR HPV (6)
61.9 (31.3–88.2)21
102.3 (29.4–291.3)19
20330 (15500–33070)
16.0 (7.0–34.8)18
1039000 (595600–1249000)
106000 (93100–187900)
Control group (60)
20.6 (5.4–67.4)
44.3 (27.7–113.1)
38530 (19270–84160)
367.0 (128.6–515.3)
979056 (384200–1191000)
88230 (47960–220500)
HR and LR HPV: 6; HPV: human papillomavirus, : number of cases; ; HR: high-risk; LR: low-risk; : significant difference between the concentration of cytokines compared to control group. 10.022; 20.047; 30.040; 40.009; 50.012; 60.020; 70.029; 80.006; 90.012; 100.039; 110.053; 12<0.001; 130.0012; 140.034; 150.019; 160.061; 170.054; 18<0.0001. : significant difference between the concentration of cytokines compared only BV to HPV infection: 19<0.0001; 200.020; 210.005; 220.060.
