Table of Contents
ISRN Pharmaceutics
Volume 2012 (2012), Article ID 364261, 10 pages
http://dx.doi.org/10.5402/2012/364261
Research Article

Response Surface Optimization of Sustained Release Metformin-Hydrochloride Matrix Tablets: Influence of Some Hydrophillic Polymers on the Release

1Department of Pharmaceutics, Himalayan Pharmacy Institute, East Sikkim, Majhitar, India
2Department of computer Sciences, Dr. B.C. Roy Engineering College, Durgapur 713206, India
3College of Pharmacy, Gupta College of Technological Sciences, Asansol, Burdwan 713301, India
4Bengal College of Pharmaceutical Sciences and Research, Bidhannagar, Durgapur 713212, India
5Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India

Received 28 March 2012; Accepted 21 May 2012

Academic Editors: H. I. Gul and C. Xia

Copyright © 2012 Amitava Roy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of the present work was designed to develop a model-sustained release matrix tablet formulation for Metformin hydrochloride using wet granulation technique. In the present study the formulation design was employed to statistically optimize different parameters of Metformin hydrochloride tablets at different drug-to-polymer ratios employing polymers Hydroxypropyl methylcellulose of two grades K4M and K100M as two independent variables whereas the dependent variables studied were 𝑋60, 𝑋120, 𝑇50, 𝑇90, n, and b values obtained from dissolution kinetics data. The in vitro drug release studies were carried out at simulated intestinal fluids, and the release showed a non-Fickian anomalous transport mechanism. The drug release was found to reveal zero order kinetics. The granules and the tablets were tested for their normal physical, morphological, and analytical parameters and were found to be within the satisfactory levels. There were no significant drug-polymer interactions as revealed by infrared spectra. It has been found out that on an optimum increased Hydroxypropyl methylcellulose K100M concentration and decreased Hydroxypropyl methylcellulose K4M concentration the formulations were elegant in terms of their release profiles and were found to be statistically significant and generable.