Response Surface Optimization of Sustained Release Metformin-Hydrochloride Matrix Tablets: Influence of Some Hydrophillic Polymers on the Release

Table 1

Formulation design of Met-HCl matrix tablets.

Sl. no.	Ingredients (mg)	Formulation
		FF1	FF2	FF3	FF4	FF5	FF6
1	Metformin HCl	500	500	500	500	500	500
2	Microcrystalline cellulose	101	100.2	99.3	98.4	97.5	96.6
3	HPMC K4M (X1)	103.8	102.9	102	101.2	100.3	99.4
4	HPMC K100M (X2)	145.2	146.9	148.7	150.4	152.2	154
5	Povidone K30	20	20	20	20	20	20
6	Magnesium stearate	5	5	5	5	5	5
7	Talc	5	5	5	5	5	5