Response Surface Optimization of Sustained Release Metformin-Hydrochloride Matrix Tablets: Influence of Some Hydrophillic Polymers on the Release

Table 3

Evaluation of tablets.

		Evaluating parameters
Sl. no.	Batch code	Wt. variation; (mg)	Hardness; (kg/cm^2)	Thickness; (mm)	Friability; (%)	Disintegration time; (hr. min.)	Drug content; (%)
1	FF1	878.87±2.35	6.6±0.16	6.29±0.08	0.59	3.17	499±0.84
2	FF2	881.41±2.21	6.3±0.14	6.76±0.05	0.46	3.03	499.4±0.31
3	FF3	880.12±1.91	7.8±0.21	6.42±0.07	0.63	2.44	499.7±0.56
4	FF4	878.86±3.16	6.1±0.19	6.36±0.03	0.39	2.5	498.9±1.21
5	FF5	879.23±2.86	7.6±0.23	6.01±0.09	0.78	2.37	499.2±0.67
6	FF6	882.36±1.78	7.9±0.16	5.99±0.08	0.21	2.52	498.4±1.12

All values represent mean ± SD (𝑛=6).