Response Surface Optimization of Sustained Release Metformin-Hydrochloride Matrix Tablets: Influence of Some Hydrophillic Polymers on the Release

Table 4

Values obtained after fitting the drug release data of all formulations to different kinetic model.

Batch code	Zero order		First order		Higuchi model
	𝑅^2	𝐾0	𝑅^2	𝐾1	𝑅^2	kH
FF1	0.894	7.741	0.994	−0.13	0.975	0.031
FF2	0.918	8.508	0.972	−0.14	0.944	0.028
FF3	0.907	8.673	0.933	−0.124	0.924	0.027
FF4	0.915	8.471	0.882	−0.118	0.931	0.028
FF5	0.967	8.944	0.953	−0.135	0.928	0.027
FF6	0.972	8.202	0.94	−0.117	0.957	0.03