Research Article
Simple Methods for the Spectrophotometric Determination of Carvedilol
Table 2
Analytical parameters.
| | Method A | Method B |
|
(nm) | 601 | 662 | Beer’s law limit (μg mL−1) | 50.00–250.00 | 20.00–100.00 | Molar absorptivity (Lmol−1 cm−1) | 0.92 × 103 | 0.257 × 104 | Sandell’s sensitivity (μg cm−2) | 0.050 | 0.158 | Limit of detection** (μg mL−1) | 1.650 | 0.6626 | Limit of quantification** (μg mL−1) | 5.0000 | 2.0080 | Regression equation* | | | Slope () | 0.0020 | 0.0049 | Intercept () | 0.0124 | 0.0203 | Correlation coefficient () | 0.9988 | 0.9988 |
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*
is the absorbance and the concentration in g mL−1.
**Calculated according to ICH guidelines.
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