Bioequivalence Study of Modified-Release Gliclazide Tablets in Healthy Volunteers

Table 4

Pharmacokinetic characteristics of gliclazide from 18 volunteers following a single oral administration of 30 mg gliclazide MR tablets under fed condition.

Pharmacokinetic parameter	Products
	Test product; (Glycon MR)	Reference product; (Diamicron MR)
𝑇max (h)	5.56 ± 1.62	8.11 ± 2.65
𝐶max (ng/mL)	996.48 ± 193.85	918.33 ± 207.70
AUC0−𝑡 (ng·h/mL)	24,338.87 ± 9599.26	24,074.37 ± 8885.55
AUC0−∞ (ng·h/mL)	26,969.66 ± 12098.68	27,574.71 ± 14049.22
𝑡1/2 (h)	18.14 ± 5.54	18.74 ± 7.76
𝐾𝑒 (h^−1)	0.04 ± 0.01	0.04 ± 0.01