International Scholarly Research Notices

Clinical Study

Immunohistochemical Evaluation of Cell Cycle Regulators: Impact on Predicting Prognosis in Stage T1 Urinary Bladder Cancer

Table 4

Univariate and multivariate Cox proportional hazards analysis of progression after primary transurethral resection for T1 bladder carcinoma in the southeast healthcare region in Sweden 1992–2001.
 Univariate hazard ratio
(95% CI)		Multivariate hazard ratio
(95% CI)		 value**
Tumor size   
 ≤30 mm 1.01.0 
 >30 mm 1.28 (0.82–2.01) 1.32 (0.83–2.09) 0.24
LVI*   
 No1.01.0 
 Suspected0.99 (0.57–1.73) 0.91 (0.51–1.64)0.75
 Yes2.75 (1.40–5.41)3.41 (1.61–7.24) 0.001
p16   
 Abnormal1.01.0 
 Normal0.51 (0.31–0.83)0.46 (0.27–0.76)0.003
Cyclin D1   
 Abnormal1.01.0 
 Normal0.65 (0.41–1.04)0.82 (0.49–1.35) 0.43
p21   
 Abnormal1.01.0 
 Normal1.52 (0.88–2.64)1.43 (0.80–2.53) 0.23
p53   
 Abnormal1.01.0 
 Normal1.29 (0.78–2.13)1.41 (0.83–2.39)0.20
MMP2   
 Abnormal1.01.0 
 Normal0.90 (0.52–1.54)0.82 (0.47–1.45)0.50
MMP9   
 Abnormal1.01.0 
 Normal0.79 (0.45–1.39)0.89 (0.49–1.59)0.69
pRb   
 Abnormal1.01.0 
 Normal1.20 (0.66–2.18) 1.29 (0.70–2.38) 0.42
*LVI: lsymphovascular invasion.
** P values for variables are from multivariate Cox regression after adjusting for each other.