Table of Contents
ISRN Oncology
Volume 2012, Article ID 382010, 6 pages
Review Article

Epithelial Mesenchymal Transition: A New Insight into the Detection of Circulating Tumor Cells

Clinical Laboratory, Astralab Department of Specialized Analyses, 87000 Limoges, France

Received 15 December 2011; Accepted 13 February 2012

Academic Editors: G. Ghanem, L. Saragoni, M. Stracke, and L.-M. Sun

Copyright © 2012 Guislaine Barrière et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Many research groups reported on the relation between circulating tumor cells (CTCs) in peripheral blood and worse prognosis for metastatic cancer patients. These results are based on CTCs counting and did not take into account molecular characteristics of cells. To establish CTCs as a reliable and accurate biological marker, new technologies must be focused on CTC subpopulations: dedifferentiated circulating tumor cells (ddCTCs) arising from epithelial mesenchymal transition (EMT). To select and detect them, different methods have been proposed but none has still reached the goal. Technical progress and translational research are expected to establish CTCs as a real marker. Thus CTC evaluation profiling for each patient will lead to personalize followup and therapy.