Table of Contents
ISRN Immunology
Volume 2012, Article ID 382189, 7 pages
Clinical Study

Evaluation of the Immune Response of Individuals Infected with Mycobacterium tuberculosis and Patients with Active Tuberculosis

1Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia da Universidade Federal de Minas Gerais (UFMG), 31270-901 Belo Horizonte, MG, Brazil
2Departamento de Estatística, Escola de Enfermagem da UFMG, 30130-100 Belo Horizonte, MG, Brazil
3Departamento de Clínica Médica, Pneumologia/Tisiologia/Faculdade de Medicina da UFMG, 30130-100 Belo Horizonte, MG, Brazil

Received 22 October 2011; Accepted 23 November 2011

Academic Editor: J. Aliberti

Copyright © 2012 Tânia Mara Pinto Dabés Guimarães et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This study reports the association between Mycobacterium tuberculosis and the immune response to pulmonary tuberculosis (TB). Three groups were analyzed: (a) symptomatic patients with pulmonary tuberculosis (PTB), HIV-negative; (b) healthy individuals, tuberculin skin test reactive (TST+); (c) asymptomatic individuals, TST nonreactive (TST). Groups B and C presented a negative bacilloscopic smear, normal chest radiographs, and negative HIV. The ELISA was used for IFN-γ, IL-10, TNF-α, and IgG quantification and lymph proliferative assay (LPA) to evaluate the cellular immune response. IgG and LPA increased in all study groups as well as IFN-γ and TNF-α, but IL-10 remained low in all study groups. There was an association between LPA and IFN-γ in group B. It was demonstrated an association between IgG and IL-10 and between IFN-γ and IL-10 in group A. There were direct and significant correlations between LPA and IgG, TNF-α and IFN-γ, IL-10 and IgG, and between IL-10 and IFN-γ, but an inverse relationship was observed between IFN-γ and LPA.