Table of Contents
ISRN Immunology
Volume 2012 (2012), Article ID 382189, 7 pages
http://dx.doi.org/10.5402/2012/382189
Clinical Study

Evaluation of the Immune Response of Individuals Infected with Mycobacterium tuberculosis and Patients with Active Tuberculosis

1Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia da Universidade Federal de Minas Gerais (UFMG), 31270-901 Belo Horizonte, MG, Brazil
2Departamento de Estatística, Escola de Enfermagem da UFMG, 30130-100 Belo Horizonte, MG, Brazil
3Departamento de Clínica Médica, Pneumologia/Tisiologia/Faculdade de Medicina da UFMG, 30130-100 Belo Horizonte, MG, Brazil

Received 22 October 2011; Accepted 23 November 2011

Academic Editor: J. Aliberti

Copyright © 2012 Tânia Mara Pinto Dabés Guimarães et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Torres, T. Herrera, H. Villareal, E. A. Rich, and E. Sada, “Cytokine profiles for peripheral blood lymphocytes from patients with active pulmonary tuberculosis and healthy household contacts in response to the 30-kilodalton antigen of Mycobacterium tuberculosis,” Infection and Immunity, vol. 66, no. 1, pp. 176–180, 1998. View at Google Scholar · View at Scopus
  2. J. Turner, T. Corrah, S. Sabbally, H. Whittle, and H. M. Dockrell, “A longitudinal study of in vitro IFNγ production and cytotoxic T cell responses of tuberculosis patients in The Gambia,” Tubercle and Lung Disease, vol. 80, no. 3, pp. 161–169, 2000. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. A. A. Chackerian, T. V. Perera, and S. M. Behar, “Gamma interferon-producing CD4+ T lymphocytes in the lung correlate with resistance to infection with Mycobacterium tuberculosis,” Infection and Immunity, vol. 69, no. 4, pp. 2666–2674, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. D. Dlugovitzky, M. L. Bay, L. Rateni et al., “Influence of disease severity on nitrite and cytokine production by peripheral blood mononuclear cells from patients with pulmonary tuberculosis,” Clinical and Experimental Immunology, vol. 122, no. 3, pp. 343–349, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Oberholzer, C. Oberholzer, and L. L. Moldawer, “Cytokine signaling-regulation of the immune response in normal and critically ill states,” Critical Care Medicine, vol. 28, no. 4, pp. 3–12, 2000. View at Google Scholar · View at Scopus
  6. J. L. Flynn and J. Chan, “Immunology of tuberculosis,” Annual Review of Immunology, vol. 19, pp. 93–129, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. C. Ladel, G. Szalay, D. Riedel, and S. H. E. Kaufmann, “Interleukin-12 secretion by Mycobacterium tuberculosis-infected macrophages,” Infection and Immunity, vol. 65, no. 5, pp. 1936–1938, 1997. View at Google Scholar · View at Scopus
  8. M. Kori, V. Barak, E. Leibovitz, Y. Altman, A. Eliraz, and Z. T. Handzel, “Specific in vitro proliferative immune responses and lymphokine production in Ethiopian children with and without tuberculosis,” Infection, vol. 28, no. 1, pp. 42–45, 2000. View at Publisher · View at Google Scholar · View at Scopus
  9. T. H. Ottenhoff, F. A. Verreck, M. A. Hoeve, and E. van de Vosse, “Control of human host immunity to mycobacteria,” Tuberculosis, vol. 85, no. 1-2, pp. 53–64, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. A. Raja, “Immunology of tuberculosis,” Indian Journal of Medical Research, vol. 120, no. 4, pp. 213–232, 2004. View at Google Scholar · View at Scopus
  11. H. Burns, C. Meinken, P. Schauenberg et al., “Anti-TNF-α immunotherapy reduces CD8+ T cell-mediated antimicrobial activity against Mycobacterium tuberculosis in humans,” Journal of Clinical Investigation, vol. 119, no. 5, pp. 1167–1177, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. T. R. Mossman and K. W. Moore, “The role of IL-10 in cross regulation of Th1 and Th2 response,” Immunology Today, vol. 12, pp. A49–A53, 1991. View at Google Scholar
  13. A. D'Andrea, M. Aste-Amezaga, N. M. Valiante, X. Ma, M. Kubin, and G. Trinchieri, “Interleukin 10 (IL-10) inhibits human lymphocyte IFN-γ-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells,” Journal of Experimental Medicine, vol. 178, no. 3, pp. 1041–1048, 1993. View at Google Scholar · View at Scopus
  14. M. Rojas, M. Olivier, P. Gros, L. F. Barrera, and L. F. Garcia, “TNF-α and IL-10 modulate the induction of apoptosis by virulent Mycobacterium tuberculosis in murine macrophages,” Journal of Immunology, vol. 162, no. 10, pp. 6122–6131, 1999. View at Google Scholar · View at Scopus
  15. Brasil. Ministério da Saúde. Fundação Nacional de Saúde. Centro de Referência Professor Hélio Fraga. Sociedade de Pneumologia e Tisiologia. “Controle da Tuberculose: uma proposta de integração ensino-serviço”. 5a ed. Rio de Janeiro: FUNASA/CRPHF/SBPT, 2002.
  16. L. B. Gerald, S. Tang, F. Bruce et al., “A decision tree for tuberculosis contact investigation,” American Journal of Respiratory and Critical Care Medicine, vol. 166, no. 8, pp. 1122–1127, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. J. E. Golub, S. Bur, W. A. Cronin et al., “Delayed tuberculosis diagnosis and tuberculosis transmission,” International Journal of Tuberculosis and Lung Disease, vol. 10, no. 1, pp. 24–30, 2006. View at Google Scholar · View at Scopus
  18. C. H. Wang, H. C. Lin, T. T. Huang, C. T. Yu, and H. P. Kuo, “Upregulation of inducible nitric oxide synthase and cytokine secretion in peripheral blood monocytes from pulmonary tuberculosis patients,” International Journal of Tuberculosis and Lung Disease, vol. 5, no. 3, pp. 283–291, 2001. View at Google Scholar · View at Scopus
  19. M. Farhat, C. Greenaway, M. Pai, and D. Menzies, “False-positive tuberculin skin tests: what is the absolute effect of BCG and non-tuberculous mycobacteria?” International Journal of Tuberculosis and Lung Disease, vol. 10, no. 11, pp. 1192–1204, 2006. View at Google Scholar · View at Scopus
  20. M. B. Lurie and A. M. Dannenberg Jr., “Macrophage function in infections disease with inbread rabbits,” Bacteriology Review, vol. 29, pp. 466–476, 1965. View at Google Scholar
  21. J. L. Ho and L. W. Riley, “Defenses of the lung against tuberculosis,” in The Lung Scientific Foundations, R. Crystal, J. West, E. Weibel, and P. Barnes, Eds., pp. 2381–2394, Lippincott-Raven, New York, NY, USA, 2nd edition, 1997. View at Google Scholar
  22. M. J. Fenton, M. W. Vermeulen, S. Kim, M. Burdick, R. M. Strieter, and H. Kornfeld, “Induction of gamma interferon production in human alveolar macrophages by Mycobacterium tuberculosis,” Infection and Immunity, vol. 65, no. 12, pp. 5149–5156, 1997. View at Google Scholar · View at Scopus
  23. S. D. Lawn, L. Myer, D. Edwards, L. -G. Bekker, and R. Wood, “Short-term and long-term risk of tuberculosis associated with CD4 cell recovery during antiretroviral therapy in South Africa AIDS,” South African Medical Journal, vol. 23, no. 13, pp. 1717–1725, 2009. View at Publisher · View at Google Scholar · View at PubMed
  24. P. F. Barnes, R. L. Modlin, and J. J. Ellner, “T-cell responses and cytokines,” in Tuberculosis: Pathogenesis, Protection and Control, B. R. Bloom, Ed., chapter 25, pp. 417–435, ASM Press, Washington, DC, USA, 1993. View at Google Scholar
  25. D. Robinson, T. Ying, D. Wangoo et al., “Evidence for a Th1-like bronchoalveolar T-cell subset and predominance of interferon-gamma gene activation in pulmonary tuberculosis,” American Journal of Respiratory and Critical Care Medicine, vol. 149, no. 4, pp. 989–993, 1994. View at Google Scholar
  26. B. Raju, C. F. Tung, D. Cheng et al., “In situ activation of helper T cells in the lung,” Infection and Immunity, vol. 69, no. 8, pp. 4790–4798, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  27. N. V. Serbina and J. L. Flynn, “CD8+ T cells participate in the memory immune response to Mycobacterium tuberculosis,” Infection and Immunity, vol. 69, no. 7, pp. 4320–4328, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  28. C. A. Scanga, V. P. Mohan, K. Yu et al., “Depletion of CD4+ T cells causes reactivation of murine persistent tuberculosis despite continued expression of interferon γ and nitric oxide synthase 2,” Journal of Experimental Medicine, vol. 192, no. 3, pp. 347–358, 2000. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Gonzalez-Juarrero, O. C. Turner, J. Turner, P. Marietta, J. V. Brooks, and I. A. Orme, “Temporal and spatial arrangement of lymphocytes within lung granulomas induced by aerosol infection with Mycobacterium tuberculosis,” Infection and Immunity, vol. 69, no. 3, pp. 1722–1728, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus