Table of Contents
ISRN Pathology
Volume 2012, Article ID 387145, 13 pages
Review Article

Confocal Laser Endomicroscopy: Applications in Clinical and Translational Science—A Comprehensive Review

Innere Medizin I, Universitätsklinikum Tübingen, 72076 Tübingen, Germany

Received 7 November 2012; Accepted 11 December 2012

Academic Editors: V. J. Amatya, R. Drut, T. Kovács, and A. Wincewicz

Copyright © 2012 Martin Goetz. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Confocal laser endomicroscopy (CLE) is a novel tool in the endoscopist’s armamentarium. It allows on-site histological information. The ability of gastroenterologists to interpret such microscopic information has been demonstrated in multiple studies from the upper and lower gastrointestinal tract. Recently, the field of application has expanded to provide hepatobiliary and intra-abdominal CLE imaging. CLE allows “smart,” targeted biopsies and is able to guide endoscopic interventions. But CLE is also translational in its approach and permits functional imaging that significantly impacts on our understanding of gastrointestinal diseases. Molecular imaging with CLE allows detection and characterization of lesions and may even be used for prediction of response to targeted therapy. This paper provides a comprehensive review over current applications of CLE in clinical applications and translational science.