Table of Contents
ISRN Psychiatry
Volume 2012, Article ID 387901, 6 pages
Review Article

The Relationships between Cholesterol and Suicide: An Update

1Psychiatric Service of Diagnosis and Treatment, Department of Mental Health, “G. Mazzini” Hospital, NHS, ASL 4, 64100 Teramo, Italy
2Department of Neurosciences and Imaging, “G. D’Annunzio” University, 66013 Chieti, Italy
3Pharmaceutical Service, “G. Mazzini” Hospital, NHS, ASL 4, 64100 Teramo, Italy
4IASM, 67100 L’Aquila, Italy
5Department of Clinical Neurosciences, Villa San Benedetto Hospital, Hermanas Hospitalarias, 22032 Albese con Cassano, Italy
6Villa S. Giuseppe Hospital, Hermanas Hospitalarias, 63100 Ascoli Piceno, Italy
7Department of Health Science, University of L’Aquila, 67100 L’Aquila, Italy
8Department of Formative Sciences, University of Catania, 95100 Catania, Italy
9Laboratory of Molecular Psychiatry and Psychopharmacotherapeutics, Section of Psychiatry, Department of Neuroscience, School of Medicine, University of Naples “Federico II”, 80121 Naples, Italy

Received 6 November 2012; Accepted 25 November 2012

Academic Editors: C. M. Contreras, B. J. Mitterauer, and C. Norra

Copyright © 2012 Domenico De Berardis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cholesterol is a core component of the central nervous system, essential for the cell membrane stability and the correct functioning of neurotransmission. It has been observed that cholesterol may be somewhat associated with suicidal behaviours. Therefore, the aim of this paper was to elucidate current facts and views about the role of cholesterol levels in mood disorders. The majority of the studies reviewed in the present paper suggest an interesting relationship between cholesterol (especially lower levels) and suicidality. On the other hand, particularly during the last years, relationships between serum cholesterol and suicidality were doubted on the basis of some recent studies that have not found any correlation. However, the debate on relationships between cholesterol and suicide is open and longitudinal studies on a larger sample of patients are needed to further clarify this important issue.