Table of Contents
ISRN Surgery
Volume 2012, Article ID 389385, 5 pages
http://dx.doi.org/10.5402/2012/389385
Clinical Study

Factors Related to Long-Term Survival in Patients Affected by Well-Differentiated Endocrine Tumors of the Pancreas

1Department of Surgery, S.Orsola-Malpighi Hospital, Alma Mater Studiorum, University of Bologna, 40138 Bologna, Italy
2Department of Internal Medicine, S.Orsola-Malpighi Hospital, Alma Mater Studiorum, University of Bologna, 40138 Bologna, Italy

Received 10 April 2012; Accepted 15 May 2012

Academic Editors: S. Germanos, K.-E. Kahnberg, and A. Petroianu

Copyright © 2012 Riccardo Casadei et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. To identify factors related to survival in patients affected by well-differentiated PETs (benign, uncertain behavior, and carcinoma) who underwent R0 pancreatic resection. Methods. Retrospective study of 74 consecutive patients followed up from January 1980 to December 2011. Prognostic factors were sex, age, type of tumor, presence of symptoms, type of surgical procedure, size of tumor, lymph nodes status, WHO classification, and TNM stage. Overall survival was evaluated using the Kaplan-Meier method. Cox regression analyses were used to identify the factors associated with prognosis in univariate and multivariate analysis. Results. The mean follow-up of all the patients was 1 0 6 Β± 8 9 months. The 5–10-year long-term survival was 90.9% and 79.1%, respectively. At univariate analysis, patient age <55 years was significantly related to a better long-term survival compared to patients age ≥55 years ( 3 0 7 Β± 1 5 months versus 1 9 2 Β± 2 5 months; 𝑃 = 0 . 0 1 0 ). Multivariate analysis showed that female gender ( 𝑃 = 0 . 0 0 6 ), patients without comorbidities ( 𝑃 = 0 . 0 3 3 ), and patients affected by well-differentiated benign pancreatic endocrine tumors ( 𝑃 = 0 . 0 0 8 and 𝑃 = 0 . 0 0 2 in relation to tumors with uncertain behavior and carcinomas, resp.) were factors significantly related to a better long-term survival. Conclusions. Patients factors were strongly related to a better long-term survival in patients observed. WHO classification is a very useful prognostic tool for well-differentiated PETs.