Table of Contents
ISRN Obstetrics and Gynecology
Volume 2012, Article ID 405382, 5 pages
Review Article

A Review of Outcome Data concerning Children Born following Assisted Reproductive Technologies

1Service d'Histologie-Embryologie-Cytogénétique, Laboratoire de Biologie de la Reproduction, Centre Hospitalier Universitaire Jean Verdier, Assistance Publique-Hôpitaux de Paris, 93140 Bondy, France
2Service d'Histologie-Embryologie-Cytogénétique, Hôpital Jean Verdier, 93140 Bondy, France

Received 20 September 2011; Accepted 6 March 2012

Academic Editors: J. G. Schenker and K. Yang

Copyright © 2012 Charlotte Dupont and Christophe Sifer. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Assisted reproductive technologies (ARTS) are used for more than 30 years to help infertile couples. Concerns about long-term health of children conceived following ART have led to start follow-up studies. Despite methodological limitations and discrepant results, many of the studies and meta-analyses have reported an increased risk of birth defects after ART. Etiologies may be multiple births, a major drawback of ART, parents' subfertility, or technologies themselves. Prematurity and intrauterine growth retardation (IUGR) seem to cause most of the pathologies reported in ART children. Nevertheless, epigenetic disorders need to be followed up since increases of imprinting diseases were reported. Consequently, alteration of gametes and early embryo development with ART may have consequences on children health since periconceptional period is critical for long-term development. Yet general condition of most of children conceived with ART is reassuring, but long-term followup is still strongly needed.