Modulating Anti-MicroRNA-21 Activity and Specificity Using Oligonucleotide Derivatives and Length Optimization
Oligonucleotide length effects on AMO activity. Fold increase of luciferase activity after wild-type AMO treatment at three different concentrations, 100 nM, 50 nM, and 25 nM. Five different lengths were used, a 22-, 18-, 15-, 12-, and 9-mer (data not shown) ONs. All AMOs had a phosphodiester (PO) backbone.