Modulating Anti-MicroRNA-21 Activity and Specificity Using Oligonucleotide Derivatives and Length Optimization

<table>Oligonucleotide length effects on AMO activity. Fold increase of luciferase activity after wild-type AMO treatment at three different concentrations, 100 nM, 50 nM, and 25 nM. Five different lengths were used, a 22-, 18-, 15-, 12-, and 9-mer (data not shown) ONs. All AMOs had a phosphodiester (PO) backbone.</table>

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Figure 1: Modulating Anti-MicroRNA-21 Activity and Specificity Using Oligonucleotide Derivatives and Length Optimization 