Modulating Anti-MicroRNA-21 Activity and Specificity Using Oligonucleotide Derivatives and Length Optimization

<table>Influence of oligonucleotide length on AMO specificity. Fold increase of luciferase activity posttreatment at 100 nM concentration with a 32% LNA 22-mer AMO and 33% LNA 18-mer, both with phosphodiester backbone. The 18-mer AMO has a comparative activity to that of the 22-mer AMO but the AMO with two mismatches has lower activity than the corresponding 22-mer with two mismatches, indicating better sequence specificity for target miR21.</table>

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Figure 2: Modulating Anti-MicroRNA-21 Activity and Specificity Using Oligonucleotide Derivatives and Length Optimization 