Modulating Anti-MicroRNA-21 Activity and Specificity Using Oligonucleotide Derivatives and Length Optimization

<table>Influence of phosphorothioates on AMO activity. Fold increase of luciferase activity after wild-type AMO treatment at 100 nM, 50 nM, 25 nM, and 10 nM concentrations. The AMO activity was at all concentrations significantly greater for the phosphorothioate (PS) ONs than the activity of the phosphodiester ONs.</table>

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Figure 3

Figure 3: Modulating Anti-MicroRNA-21 Activity and Specificity Using Oligonucleotide Derivatives and Length Optimization 