Stability-Indicating HPTLC-Densitometric Method for Estimation of Dorzolamide Hydrochloride in Eye Drops

<table>Densitogram of the acid degradation product 300 ng/spot; condition: 1 M HCl at room temperature for 2 h; peak 1 (dorzolamide hydrochloride, <svg height="16.2875" id="M5" style="vertical-align:-4.77652pt" version="1.1" viewbox="0 0 19.700001 16.2875" width="19.700001" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,16.2875)">
<g transform="translate(72,-58.97)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑅</tspan>
</text>
<text transform="matrix(1,0,0,-1,-62.7,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">𝑓</tspan>
</text>
</g>
</g>
</svg>: 0.29), peak  2 (degraded, <svg height="16.2875" id="M6" style="vertical-align:-4.77652pt" version="1.1" viewbox="0 0 19.700001 16.2875" width="19.700001" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,16.2875)">
<g transform="translate(72,-58.97)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑅</tspan>
</text>
<text transform="matrix(1,0,0,-1,-62.7,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">𝑓</tspan>
</text>
</g>
</g>
</svg>: 0.33).</table>

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Figure 3

Figure 3: Stability-Indicating HPTLC-Densitometric Method for Estimation of Dorzolamide Hydrochloride in Eye Drops 