Table of Contents
ISRN Analytical Chemistry
Volume 2012, Article ID 414075, 7 pages
http://dx.doi.org/10.5402/2012/414075
Research Article

Stability-Indicating HPTLC-Densitometric Method for Estimation of Dorzolamide Hydrochloride in Eye Drops

1Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth University, Maharashtra, Pune 411038, India
2Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, , , RAK Medical & Health Sciences University, P.O. Box 11172, Ras Al-Khaimah, UAE

Received 26 March 2012; Accepted 7 May 2012

Academic Editors: J. N. Latosinska and K. Ohyama

Copyright © 2012 S. S. Havele and S. R. Dhaneshwar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. USP DI, Advice for the Patient, Drug Information in Lay Language, vol. II, Micromedex, Ankeny, Iowa, USA, 19th edition, 1999.
  2. M. L. Constanzer, C. M. Chavez, and B. K. Matuszewski, “Low level determination of dorzolamide and its de-ethylated metabolite in human plasma by liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry,” Journal of Pharmaceutical and Biomedical Analysis, vol. 15, no. 7, pp. 1001–1008, 1997. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Maltese and C. Bucolo, “Rapid high-performance liquid chromatographic assay of dorzolamide in rabbit aqueous humor,” Biomedical Chromatography, vol. 16, no. 4, pp. 274–276, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. R. C. Tim, R. A. Kautz, and B. L. Karger, “Ultratrace analysis of drugs in biological fluids using affinity probe capillary electrophoresis: analysis of dorzolamide with fluorescently labelled carbonic anhydrase,” Electrophoresis, vol. 21, no. 1, pp. 220–226, 2000. View at Google Scholar
  5. A. Zammataro, R. Saletti, C. Civiale, V. Muccilli, V. Cunsolo, and S. Foti, “Simultaneous quantification of carteolol and dorzolamide in rabbit aqueous humor and ciliary body by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry,” Journal of Chromatography B, vol. 878, no. 9-10, pp. 807–814, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Dovletoglou, S. M. Thomas, L. Berwick, D. K. Ellison, and P. C. Tway, “Development of practical HPLC methods for analysis and quality assessment of the novel carbonic anhydrase inhibitor MK-0507 and the acetamidosulfonamide intermediate,” Journal of Liquid Chromatography, vol. 18, no. 12, pp. 2337–2352, 1995. View at Google Scholar · View at Scopus
  7. N. Erk, “Rapid and sensitive HPLC method for the simultaneous determination of dorzolamide hydrochloride and timolol maleate in eye drops with diode-array and UV detection,” Pharmazie, vol. 58, no. 7, pp. 491–493, 2003. View at Google Scholar · View at Scopus
  8. R. Kanchan, S. M. N. Roy, and R. B. Rane, “Simultaneous RP-HPLC determination of dorzolamide hydrochloride and timolol maleate in pharmaceutical preparations,” Trade Science Inc., vol. 7, no. 8, 2008. View at Google Scholar
  9. T. J. Novak and L. Berwick, “Determination of the enantiomeric composition of a novel topically active carbonic anhydrase inhibitor by HPLC,” Journal of Liquid Chromatography and Related Technologies, vol. 21, no. 12, pp. 1883–1896, 1998. View at Google Scholar · View at Scopus
  10. L. I. Bebawy, “Application of TLC-densitometry, first-derivative UV-spectrophotometry and ratio derivative spectrophotometry for the determination of dorzolamide hydrochloride and timolol maleate,” Journal of Pharmaceutical and Biomedical Analysis, vol. 27, no. 5, pp. 737–746, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. N. Erk, “Simultaneous determination of dorzolamide HCL and timolol maleate in eye drops by two different spectroscopic methods,” Journal of Pharmaceutical and Biomedical Analysis, vol. 28, no. 2, pp. 391–397, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. I. M. Palabiyik, M. G. Caglayan, and F. Onur, “Multivariate optimization and validation of a CE method for simultaneous analysis of dorzolamide hydrochloride and timolol maleate in ophthalmic solution,” Chromatographia, vol. 73, no. 5-6, pp. 541–548, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. N. Erk, “Voltammetric and HPLC determination of dorzolamide hydrochloride in eye drops,” Pharmazie, vol. 58, no. 12, pp. 870–873, 2003. View at Google Scholar · View at Scopus
  14. S. Saǧlik, “Determination of dorzolamide in ophthalmic solutions using solid-phase extraction by high-performance liquid chromatography,” Acta Pharmaceutica Turcica, vol. 42, no. 2-3, pp. 98–100, 2000. View at Google Scholar · View at Scopus
  15. H. M. Sharath, G. Jose, K. P. Channabasavaraj, and J. S. Modiya, “Development and validation of spectrophotometric methods for Estimation of dorzolamide HCL in bulk and pharmaceutical dosage forms,” International Journal of Pharmaceutical Sciences and Research, vol. 2, no. 4, pp. 948–953, 2011. View at Google Scholar · View at Scopus
  16. Code Q2A-Text on Validation of Analytical Procedure Step-3 Consensus Guideline, ICH Harmonised Tripartite Guideline, 1994.
  17. Code Q2B-Validation of Analytical Procedure Methodology Step-4 Consensus Guideline, ICH Harmonised Tripartite Guideline, 1994.
  18. Code Q2A-Text on Validation of Analytical Procedure Step-3 Consensus Guideline, ICH Harmonised Tripartite Guideline, 1994.
  19. Code Q2B-Validation of Analytical Procedure Methodology Step-4 Consensus Guideline, ICH Harmonised Tripartite Guideline, 1994.