Table of Contents
ISRN Organic Chemistry
Volume 2012, Article ID 415645, 6 pages
Research Article

A Green, Expeditious, One-Pot Synthesis of 3, 4-Dihydropyrimidin-2(1H)-ones Using a Mixture of Phosphorus Pentoxide-Methanesulfonic Acid at Ambient Temperature

1School of Chemical Sciences, North Maharashtra University, Jalgaon 425 001, India
2Department of Pharmacology, R. C. Patel Institute of Pharmaceutical Education & Research, Shirpur 425 405, India

Received 4 April 2012; Accepted 25 June 2012

Academic Editors: J. Drabowicz, H. A. Jimenez-Vazquez, F. Machetti, F. C. Pigge, and H. Wakamatsu

Copyright © 2012 Amulrao Borse et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


An expeditious, one-pot method for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones using a mixture of phosphorus pentoxide-methanesulfonic acid (Eaton’s reagent) at room temperature under solvent-free conditions is described. The salient features of this method include short reaction time, green aspects, high yields, and simple procedure.