Pharmacokinetics and Biodistribution Study of 7A7 Anti-Mouse Epidermal Growth Factor Receptor Monoclonal Antibody and Its F(ab^′)_𝟐 Fragment in an Immunocompetent Mouse Model

Table 2

Pharmacokinetic parameters of 7A7 mAb (2.8 mg per Kg) or 7A7 F(ab′)₂ fragment (1.86 mg per Kg) after a single i.v. injection in C57BL/6 mice (𝑛=3).

	Pharmacokinetic parameters of 7A7 mAb and 7A7 F(ab′)2 fragment in C57BL/6 mice
	𝑡1/2𝛽 (h)	AUC (𝜇g/mL·h)	CL (mL/h)	Vss (mL)
7A7 mAb	23.9±0.7	1680.8±6.9	0.033±0.001	1.11±0.01
7A7 F(ab′)2	2.25±0.2	124.1±5.6	0.300±0.007	0.94±0.03

Data are expressed as the mean ± SD.
𝑡_1/2: eliminati on half-life; AUC: area under the curve; CL: clearance; Vss: volume of the distribution at a steady state.