Table of Contents
ISRN Obesity
Volume 2012, Article ID 424010, 4 pages
Research Article

Associations of Body Mass Index (Maternal BMI) and Gestational Diabetes Mellitus with Neonatal and Maternal Pregnancy Outcomes in a Multicentre European Database (Diabetes and Pregnancy Vitamin D and Lifestyle Intervention for Gestational Diabetes Mellitus Prevention)

1School of Medicine, Clinical Science Institute, National University of Ireland, Galway, Ireland
2Akademia Medyczna im Karola Marcinkowskiego, 60-512 Poznan, Poland
3Department of Medicine, Medical University of Vienna, 1090 Vienna, Austria
4Dipartimento di Endocrinologia e Malattie del Metabolismo, Università di Pisa, 56126 Pisa, Italy
5Dipartimento Scienze Mediche e Chirurgiche, Università degli Studi di Padova, 35122 Padova, Italy
6Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain
7Institute of Metabolic Science, Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK
8Department of Obstetrics, Rigshospitalet, University Hospital of Copenhagen, 2100 Copenhagen, Denmark
9Department of Obstetrics and Gynecology, Medical University of Graz, 8036 Graz, Austria
10University Hospitals Leuven, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
11Recherche en Sante Lawson, 9552 Bronschhofen, Switzerland
12Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, 00029 Helsinki, Finland
13BAP Health Outcomes Research, S.L, 33010 Oviedo, Spain
14Department of Public and Occupational Health, EMGO Institute, VU University Medical Center Amsterdam, 1007 MB Amsterdam, The Netherlands

Received 8 March 2012; Accepted 4 April 2012

Academic Editors: Y. Avraham, E. K. Naderali, and S. P. RamachandraRao

Copyright © 2012 Akke Vellinga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. Assess the impact of Gestational Diabetes Mellitus (GDM) and obesity on neonatal and maternal pregnancy outcomes. Methods. Cross-sectional data (3343 pregnancies) from seven European centres were included in a multilevel analysis of the association between GDM/obesity and caesarean section, macrosomia and neonatal morbidities. Results. Comparison of databases identified reporting differences between countries due to the inclusion of true population based samples or pregnancies from specialised tertiary centres, resulting in higher prevalences of GDM for some countries. The analysis showed that obesity and GDM were independent risk factors of perinatal complications. Only BMI had a dose-dependent effect on the risk of macrosomia and caesarean section. Both obesity (BMI > 30 kg/m2) and GDM were independent risk factors of neonatal morbidities. Conclusions. Obesity and GDM were independent risk factors of perinatal complications. The effect of the worldwide obesity and diabetes epidemic is extending to the next generation.