Table of Contents
ISRN Pharmaceutics
Volume 2012, Article ID 428396, 6 pages
Research Article

Ondansetron HCl Microemulsions for Transdermal Delivery: Formulation and In Vitro Skin Permeation

1Department of Pharmaceutics, Bengal College of Pharmaceutical Science and Research, Durgapur 713212, India
2Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj 757086, India

Received 13 March 2012; Accepted 6 May 2012

Academic Editors: M. AghazadehTabrizi, R. Lesyk, and S. Velaga

Copyright © 2012 Jadupati Malakar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Ondansetron HCl delivery through oral route suffers due to its low bioavailability due to first-pass metabolism. Therefore, the microemulsion-based transdermal delivery may be a better substitute for it. The pseudoternary phase diagrams were constructed to determine compositions of microemulsions, and ondansetron HCl microemulsions for transdermal delivery were developed using isopropyl myristate or oleic acid as the oil phase, Tween 80 as the surfactant, and isopropyl alcohol as the cosurfactant evaluated for in vitro skin permeation through excised porcine skin. The in vitro skin permeation from these formulated microemulsions was sustained over 24 hours. The microemulsion F-8 (contained 10% of isopropyl myristate as oil phase, 8% of aqueous phase, and 82% of surfactant phase containing Tween 80 and isopropyl alcohol, 3 : 1) showed the highest permeation flux of 0 . 2 8 4 ± 0 . 0 0 3 μg/cm2/hour. All these microemulsions followed the Korsmeyer-Peppas model ( 𝑅 2 = 0 . 9 7 1 t o 0 . 9 9 8 ) with non-Fickian, “anomalous” mechanism over a period of 24 hours.