Table of Contents
ISRN Pharmacology
Volume 2012, Article ID 436857, 6 pages
http://dx.doi.org/10.5402/2012/436857
Review Article

Remedial Prospective of Hippophae rhamnoides Linn. (Sea Buckthorn)

1Department of Pharmacology, SSR College of Pharmacy, Sayli-Silvassa Road, Sayli, UT oF Dadra & Nagar Haveli 396230, India
2Department of Pharmacology, Acharya & B. M. Reddy College of Pharmacy, Chikkabanavara, Bangalore 560090, India
3Department of Pharmacology, Rofel Shri G.M. Bilakhia College of Pharmacy, Namdha Road, Vapi 396191, India
4Department of Pharmaceutics, SSR College of Pharmacy, Sayli-Silvassa Road, Sayli, UT oF Dadra & Nagar Haveli 396230, India

Received 18 November 2011; Accepted 28 December 2011

Academic Editors: K. Cimanga, J. C. Laguna, and M. Tohda

Copyright © 2012 Chirag A. Patel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Sea buckthorn (Hippophae rhamnoides L.) constitutes thorny nitrogen fixing deciduous shrub. Sea buckthorn(SBT) is primarily valued for its very rich vitamins A, B1, B12, C, E, K, and P; flavonoids, lycopene, carotenoids, and phytosterols. and therapeutically important since it is rich with potent antioxidants. Scientifically evaluated pharmacological actions of SBT are like inflammation inhibited by reduced permeability, loss of follicular aggregation of lymphocytes from the inflamed synovium and suppress lymphocyte proliferation. SBT-reduced recurrence of angina, ischemic electrocardiogram which might be due to decreased myocardial oxygen consumption and inhibition of platelet aggregation induced by collagen. SBT can kill both cancer cells of S180, P388, SGC7901 and lymphatic leukemia (L1200). The antiulcer activity may be related to reduce gastric empty time, inhibiting proteolytic activity and promoting wound reparation processes of mucosa. SBT exerts antihypertensive effect in part by blocking angiotensin-2 receptor on cell surface. SBT decreased the level of stress hormones and enhanced hypoxic tolerance in animals indicating its anti-stress, adaptogenic activity. A lot of research work is still needed to find cellular and molecular mechanisms of these activities and also yet to be explored for its activity in osteoporosis, hemorrhage, cataract, urinary stone, acne, psoriasis, polyneuritis, cheilosis, glossities, baldness, anti-obesity, gout, and chronic prostitis.