Table of Contents
ISRN Pharmaceutics
Volume 2012 (2012), Article ID 438342, 5 pages
http://dx.doi.org/10.5402/2012/438342
Research Article

Development and Evaluation of Sustained Release Tablet of Betahistine Hydrochloride Using Ion Exchange Resin Tulsion T344

Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Near Karvand Naka, Maharashtra, Shirpur 425405, India

Received 20 March 2012; Accepted 23 April 2012

Academic Editors: M. Nath, K.-M. Sim, and J. Torrado

Copyright © 2012 Vijay D. Wagh and Nilesh Pawar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

An attempt was made to sustain the release of Betahistine hydrochloride by complexation technique using strong cation-exchange resin, Tulsion T344. The drug loading onto ion-exchange resin was optimized for mixing time, activation, effect of pH, swelling time, ratio of drug : resin, and temperature. The resinate was evaluated for micromeritic properties and characterized using XRPD and IR. For resinate sustained release tablets were formulated using hydoxypropyl methylcellulose K100M. The tablets were evaluated for hardness, thickness, friability, drug content, weight variation, and in vitro drug release. Tablets thus formulated (Batch T-3) provided sustained release of drug over a period of 12 h. The release of Betahistine HCl from resinate controls the diffusion of drug molecules through the polymeric material into aqueous medium. Results showed that Betahistine HCl was formulated into a sustained dosage form as an alternative to the conventional tablet.