Pharmacokinetic-Pharmacodynamic Model of Newly Developed Dexibuprofen Sustained Release Formulations

Table 3

Pain response versus plasma concentration of dexibuprofen (test product).

Time points; (h)	Pain response						Plasma concentration; (𝜇g/mL)
	V1^a	V2^a	V3^a	V4^a	V5^a	V6^a	V1^a	V2^a	V3^a	V4^a	V5^a	V6^a
0	1.1	0.5	2.3	1.4	2.4	1	0	0	0	0	0	0
2	5.1	3.5	5.4	4.4	5.7	4.1	7.1254	7.5624	5.2039	8.1283	6.9584	7.9892
4	9.3	8.6	9.4	9.1	9.7	9.8	13.5241	10.0548	12.5264	11.9856	9.5321	12.6354
6	9.9	9.6		9.8	9.9		9.1032	12.1627	9.9287	9.9012	12.9658	8.7541

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