Table of Contents
ISRN Vascular Medicine
Volume 2012, Article ID 451730, 5 pages
Clinical Study

Relation of High-Density Lipoprotein Cholesterol and Apoprotein A1 Levels with Presence and Severity of Coronary Obstruction

1Thrombosis and Atherosclerosis Unit, Fundación para la Investigación y Docencia de las Enfermedades Cardiovasculares (FIDEC), c/ Gurtubay s/n, 48013 Bilbao, Spain
2Basque Country University School of Nursing, UPV/EHU, Barrio Sarriena s/n, 48940 Leioa, Spain
3Cardiology Department, Basurto Hospital, Avenida Montevideo no. 18, 48013 Bilbao, Spain

Received 17 February 2012; Accepted 30 March 2012

Academic Editors: B. Hambly, T. Nishida, and P. Schoenhagen

Copyright © 2012 Y. Sáez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this work was to investigate the relationship between different lipids parameters with presence and severity of coronary obstruction angiographically evaluated. 897 patients (629 men and 268 women) underwent an angiography and blood extraction to determine concentrations of lipid markers: total cholesterol (TC), HDL cholesterol (HDLc), triglycerides, LDL cholesterol (LDLc), apolipoprotein A1 (apoA1), apolipoprotein B100 (apoB), non-HDL cholesterol and total cholesterol/HDLc, apoB100/apoA1 and LDLc/HDLc ratios. Multivariate analysis revealed that low HDLc levels were independently associated with the presence of coronary obstruction (OR: 0.982, 95% CI 0.969–0.996). In relation to severity of coronary stenosis, only apoA1 levels (OR: 0.990, 95% CI 0.980–1.000) and apoB/apoA1 ratio (OR: 3.243, 95% CI 1.095–9.608) were independent predictors. Our study demonstrated that HDLc was the only lipid parameter negatively and significantly associated with the presence of coronary obstruction, whereas apoA1 levels and apoB/apoA1 ratio were independent predictors of stenosis severity.