Table of Contents
ISRN Pharmacology
Volume 2012, Article ID 478023, 7 pages
http://dx.doi.org/10.5402/2012/478023
Research Article

Beneficial Effects of Pentanema vestitum Linn. Whole Plant on the Glucose and Other Biochemical Parameters of Alloxan Induced Diabetic Rabbits

1Department of Zoology, University of Malakand, Chakdara, Dir Lower 25000, Khyber Pakhtunkhwa, Pakistan
2Department of Botany, University of Malakand, Chakdara, Dir Lower 25000, Khyber Pakhtunkhwa, Pakistan
3Department of Biotechnology, University of Malakand, Chakdara, Dir Lower 25000, Khyber Pakhtunkhwa, Pakistan

Received 9 August 2012; Accepted 12 September 2012

Academic Editors: F. J. Miranda, T. B. Vree, and S.-N. Wu

Copyright © 2012 Ikram Ilahi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The residents of Lower Dir and Malakand agency, Khyber Pakhtunkhwa, Pakistan, use the dry powder of whole plant of Pentanema vestitum for the treatment of asthma and diabetes. No documented reports are available about the therapeutic action of Pentanema vestitum. The present study was aimed to explore the antihyperglycemic effect of 70% methanol extract of Pentanema vestitum whole plant in glucose-induced nondiabetic hyperglycemic and alloxan-induced diabetic rabbits. During this study, the effects of plant extract on the serum lipid profile, GPT, ALP, bilirubin and creatinine of diabetic rabbits were also studied. The extract of Pentanema vestitum whole plant exhibited significant antihyperglycemic activity in glucose-induced hyperglycemic rabbits. Treatment of alloxan-induced diabetic rabbits with extract significantly reduced the elevated levels of serum glucose, GPT, ALP, bilirubin and creatinine. During the study of lipid profile, the extract proved to be antihyperlipidemic and HDL boosting in diabetic rabbit models. From the finding of the present research, it was concluded that the 70% methanol extract of Pentanema vestitum whole plant has beneficial effects on serum levels of glucose, lipid profile, GPT, ALP, bilirubin, and creatinine of diabetic rabbits.