International Scholarly Research Notices

Research Article

Anti-Inflammatory, Analgesic, and Antipyretic Activities of the Ethanol Extract of Piper interruptum Opiz. and Piper chaba Linn.

Table 1

Effects of PI and PC extracts on granuloma formation and transudation in cotton pellet-induced granuloma formation in rats.
Dose (mg/kg)Granuloma wet weight (mg)Granuloma dry weight (mg)Transudative weight (mg)Granuloma weight (mg/mg cotton)GI (%)
Control— 5 1 8 . 4 ± 5 8 . 1 9 1 . 0 ± 8 . 2 4 2 7 . 4 ± 5 0 . 2 3 . 5 ± 0 . 4
Prednisolone5 2 8 9 . 9 ± 1 0 . 8 ∗ 6 6 . 6 ± 4 . 7 ∗ 2 2 3 . 3 ± 8 . 6 ∗ 2 . 3 ± 0 . 2 ∗ 34
Aspirin300 4 7 3 . 9 ± 2 5 . 7 9 9 . 2 ± 9 . 2 3 7 4 . 7 ± 2 2 . 6 4 . 0 ± 0 . 5 0
PI extract1,200 3 4 9 . 0 ± 3 0 . 9 ∗ 8 6 . 4 ± 9 . 1 2 6 2 . 6 ± 2 4 . 2 ∗ 3 . 3 ± 0 . 4 6
PC extract1,200 2 5 3 . 9 ± 1 5 . 3 ∗ 5 8 . 2 ± 3 . 6 ∗ 1 9 6 . 7 ± 1 3 . 0 ∗ 1 . 9 ± 0 . 2 ∗ 46
Data represent mean ± S.E.M. ( 𝑛 = 6 ). *Significantly different from the control group, 𝑃 < 0 . 0 5 .
GI: granuloma inhibition = (Granuloma weight in test group/Granuloma weight in control group) × 100.