Table of Contents
ISRN Microbiology
Volume 2012, Article ID 484176, 6 pages
http://dx.doi.org/10.5402/2012/484176
Research Article

Chromosomal Arrangement of AHL-Driven Quorum Sensing Circuits in Pseudomonas

1Faculty of Information Technology, Pázmány Péter Catholic University, Práter u. 50/a, 1083 Budapest, Hungary
2Bioinformatics Group, Biological Research Center, Temesvári krt 62, 6726 Szeged, Hungary
3Microbiology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 32149 Trieste, Italy
4Protein Structure and Bioinformatics Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 32149 Trieste, Italy

Received 26 October 2011; Accepted 16 November 2011

Academic Editors: A. Hamood, S. Heeb, and S. Matthijs

Copyright © 2012 Zsolt Gelencsér et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pseudomonas spp. are able to colonize a large variety of environments due to their wide adaptability which is also associated with an N-acyl homoserine lactone (AHL) gene regulation mechanism called quorum sensing (QS). In this article we present a systematic overview of the genomic arrangement patterns of quorum sensing genes found in Pseudomonas and compare the topologies with those found in other bacterial genomes. We find that the topological arrangement of QS genes is more variable than previously thought but there are a few unifying features that occur in many of the topological arrangements. We hypothesize that the negative regulators of QS that are often found between the canonical luxR/ and luxI-family genes may be crucial for stabilizing the output of QS circuits.