Table of Contents
ISRN Oncology
Volume 2012, Article ID 493283, 9 pages
Review Article

Integrin Signaling in Mammary Epithelial Cells and Breast Cancer

Molecular Medicine Program, Biomedical Genetics Section, Department of Medicine, Boston University School of Medicine, 72 East Concord Street, L320, Boston, MA 02118, USA

Received 9 October 2011; Accepted 30 October 2011

Academic Editors: A. Sapino, Y. Yamamoto, and Y. Yu

Copyright © 2012 Arthur W. Lambert et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cells sense and respond to the extracellular matrix (ECM) by way of integrin receptors, which facilitate cell adhesion and intracellular signaling. Advances in understanding the mammary epithelial cell hierarchy are converging with new developments that reveal how integrins regulate the normal mammary gland. But in breast cancer, integrin signaling contributes to the development and progression of tumors. This paper highlights recent studies which examine the role of integrin signaling in mammary epithelial cells and their malignant counterparts.