Table of Contents
ISRN Neurology
Volume 2012 (2012), Article ID 498303, 7 pages
Clinical Study

Spontaneous Primary Intraventricular Hemorrhage: Clinical Features and Early Outcome

1Unidad de Enfermedades Cerebrovasculares, Departamento de Neurología, Capio-Hospital Universitari del Sagrat Cor, Universitat de Barcelona, Catalonia, 08029 Barcelona, Spain
2CIBER de Enfermedades Respiratorias (CB06/06), Instituto de Salud Carlos III, Madrid, Spain
3Direcció d’Organització i Sistemes d’Informació, Gerència Territorial Metropolitana Nord, Institut Català de la Salut (ICS), Badalona, Catalonia, Barcelona, Spain

Received 29 June 2012; Accepted 22 July 2012

Academic Editors: A. Lagares and R. L. Macdonald

Copyright © 2012 Adrià Arboix et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. Primary hemorrhage in the ventricular system without a recognizable parenchymal component is very rare. This single-center retrospective study aimed to further characterize the clinical characteristics and early outcome of this stroke subtype. Methods. All patients with primary intraventricular hemorrhage included in a prospective hospital-based stroke registry over a 19-year period were assessed. A standardized protocol with 161 items, including demographics, risk factors, clinical data, neuroimaging findings, and outcome, was used for data collection. A comparison was made between the groups of primary intraventricular hemorrhage and subcortical intracerebral hemorrhage. Predictors of primary intraventricular hemorrhage were identified by logistic regression analysis. Results. There were 12 patients with primary intraventricular hemorrhage (0.31% of all cases of stroke included in the database) and 133 in the cohort of subcortical hemorrhage. Very old age (≥85 years) (odds ratio (OR) 9.89), atrial fibrillation (OR 8.92), headache (OR 6.89), and altered consciousness (OR 4.36) were independent predictors of intraventricular hemorrhage. The overall in-hospital mortality rate was 41.7% (5/12) but increased to 60% (3/5) in patients aged 85 years or older. Conclusion. Although primary intraventricular hemorrhage is uncommon, it is a severe clinical condition with a high early mortality. The prognosis is particularly poor in very old patients.